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When Rachel Ames disappears after leaving a strange message on her sister's answering machine, Liz Ames heads to Key West to find out what's happened. Within a few days of her arrival, the area is plagued by a mysterious suicide, another disappearance and the murder of a teenage girl. With the help of a former cop, she begins to uncover an evil that they may not be able to escape, even at a . . . "Dead Run.